Dose-Response Study of N,N-Dimethyltryptamine in Humans
Archives of General Psychiatry February 1, 1994 Ruck J. Strassman 454 citations
Intravenous DMT produces rapid, intense hallucinogenic effects that peak within two minutes and resolve within half an hour, closely tracking blood levels. At higher doses (0.2 and 0.4 mg/kg), volunteers experienced brightly colored, rapidly moving visual images, a dissociative state with alternating euphoria and anxiety, and a complete replacement of ongoing mental experience. Lower doses (0.05–0.1 mg/kg) primarily caused emotional and bodily sensations, with 0.1 mg/kg producing the least desirable effects. A new Hallucinogen Rating Scale captured dose-related differences better than biological measures, offering a tool for comparing DMT with other agents affecting brain receptors.