Default mode network connectivity in stable vs progressive mild cognitive impairment
Neurology January 13, 2011 Jeffrey R. Petrella, Forrest Sheldon, Steven E. Prince et al. 291 citations
Default mode network (DMN) connectivity, measured by fMRI during a face-name memory task, distinguishes people with mild cognitive impairment (MCI) who later develop Alzheimer disease (AD) from those who remain stable over 2 to 3 years. In a cohort of 68 subjects (25 normal controls, 31 MCI, 12 AD), DMN connectivity goodness-of-fit indices were highest in controls, intermediate in MCI, and lowest in AD. Among MCI subjects, baseline connectivity correlated with later decline in functional status, but added no predictive value beyond baseline delayed recall scores. The findings suggest different functional brain connectivity patterns for early versus late MCI.