Kétamine, psilocybine, et antidépresseurs d'action rapide : de nouvelles promesses pour la psychiatrie?
L Encéphale November 12, 2020 Hugo Bottemanne, A. Claret, Philippe Fossati 10 citations
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Philippe Fossati
Assistance Publique – Hôpitaux de Paris
3 papers in the library · 14 citations · publishing 2020-2026
Papers
Can we change depressive beliefs? Modulation of belief updating by ketamine in treatment resistant depression
Hugo Bottemanne, Orphée Morlaàs, Anne Claret et al. 4 citations preprint
Ketamine infusion makes people with treatment-resistant depression more optimistic about the future by changing how they learn from good and bad news. After a single infusion, patients updated their beliefs more after favorable information and less after unfavorable information, compared to healthy controls. This shift toward optimism was driven by learning more from positive surprises than negative ones. This change in belief-updating predicted early clinical improvement at one week, seen in 19% of patients. The findings suggest ketamine's antidepressant effects involve altering cognitive biases, which could enhance psychotherapy for depression.
Distinct Roles of Therapeutic Expectations and Dissociative Symptoms in Antidepressant Response During Ketamine Treatment in Routine Care
medRxiv Preprint Server April 23, 2026 Willys Cantenys, Zeynep Yoldas, Luc Masset et al. preprint
Ketamine works quickly as an antidepressant but also causes temporary dissociative symptoms. In everyday clinical settings, it is unclear how much of the antidepressant effect comes from patients' expectations versus from the dissociative experience itself, and how these factors relate to changes in depression over time.