Efeitos do tratamento com Ibogaína em dependentes de opióides: uma revisão integrativa
Brazilian Journal of Health Review December 15, 2023 Fernanda Leticia Dos Santos Matta, Vivian Frigo Batista, Alexandre Dantas Gimenes et al.
Ibogaine, a psychoactive indole alkaloid from the West African shrub Tabernanthe iboga, shows promise for treating opioid dependence by interacting with multiple neurotransmitter systems. In a systematic review of 44 studies, 7 met inclusion criteria; 6 were observational. Ibogaine treatment led to marked improvement in withdrawal symptoms (frequency, duration, intensity) and reduced opioid craving in all 7 studies. Side effects included prolonged QTc interval (4 studies), bradycardia (2), gait ataxia (2), nausea/vomiting (2), hypotension (1), and one death attributed to cardiac arrhythmia. Ibogaine may be considered for opioid-dependent adults and older adults, but requires assisted therapy with specialized professionals and attention to cardiac side effects.