Metallation/reduction as a new approach to tritium labeling. The synthesis of [3H]ibogaine
Journal of Labelled Compounds and Radiopharmaceuticals April 1, 1994 Herbert H. Seltzman, Denise F. Odear, Christopher P. Laudeman et al. 7 citations
A new method introduces tritium into aryl compounds using tritium gas directly on the underivatized substrate. By combining directed ortho metallation with a reduction of the carbon-potassium bond, tritium is incorporated at high specific activity under mild conditions. The approach is demonstrated by preparing tritium-labeled ibogaine, showing its utility for synthesizing radiolabeled compounds for research.