RTI International
2 papers in the library · 17 citations · publishing 1992-1994
Journal of the Chemical Society Chemical Communications January 1, 1992 Herbert H. Seltman, Denise F. Odear, F. Ivy Carroll et al. 10 citations
A new method for tritiating aryl compounds uses ortho metallation followed by reduction of the carbon–metal bond to produce tritium labelled ibogaine. This labelled compound is intended for pharmacological studies of ibogaine as an anti-addiction treatment for cocaine abuse.
Journal of Labelled Compounds and Radiopharmaceuticals April 1, 1994 Herbert H. Seltzman, Denise F. Odear, Christopher P. Laudeman et al. 7 citations
A new method introduces tritium into aryl compounds using tritium gas directly on the underivatized substrate. By combining directed ortho metallation with a reduction of the carbon-potassium bond, tritium is incorporated at high specific activity under mild conditions. The approach is demonstrated by preparing tritium-labeled ibogaine, showing its utility for synthesizing radiolabeled compounds for research.