Psychedelics and related compounds in cluster headache and migraine: a systematic review and meta-analysis v1
June 21, 2026 Camille Racca, Cécilie Cordier
A systematic review and meta-analysis will assess the efficacy and safety of classic serotonergic psychedelics and related ergoline or lysergamide compounds—including psilocybin, LSD, DMT, mescaline, methysergide, and others—for cluster headache and migraine. The review will synthesize evidence on changes in headache burden, safety and tolerability, quality of life, and functional impact. If enough comparable data exist, random-effects meta-analyses will be performed separately by headache disorder and compound. The protocol outlines the planned methods but does not yet report results.