Andrew Charrette

2 papers in the library · publishing 2026

Papers

Editorial: Psychedelic-assisted psychotherapies: from clinical trials to credibility

Frontiers in Neuroscience March 23, 2026 Malkanthi Evans, Andrew Charrette

Psychedelic therapies show promise for treatment-resistant depression, PTSD, anxiety, and substance-use disorders, but significant methodological and ethical challenges remain. Issues include inadequate masking in trials, expectancy effects, and reproducibility concerns. Early-phase studies indicate rapid symptom improvement, supported by neuroimaging insights, but large multisite trials with harmonized protocols and long-term follow-up are still needed. The role of psychotherapy in psychedelic-assisted treatment is debated; some developers include only psychological support. Subjective aesthetic experiences—perceptual richness, emotional resonance, beauty—are strongly linked to emotional breakthroughs and clinical outcomes. Neuroimaging shows DMT modulates brain connectivity in socio-emotional circuits. Psilocybin promotes emotional openness and cognitive flexibility. Future research must clarify mechanisms, optimize protocols, and ensure safety and generalizability.

DOI: 10.3389/fnins.2026.1816932 Full text Addiction DMT Psilocybin Emotional processing +2

Evidence in practice: implementing KAT in indigenous health services.

Frontiers in psychiatry January 1, 2026 Jean Jacque Lovely, Hiedi Yardley, Reverdi Darda et al.

A collaborative pilot program between Siksika Health Services and ATMA CENA designed and delivered a culturally responsive ketamine-assisted therapy (KAT) program within the Siksika First Nation in Alberta, Canada. Six participants (3 Indigenous, 3 non-Indigenous) completed care. Notable improvements in symptoms of depression, anxiety, and PTSD were observed, with participants reporting increased emotional regulation and stronger cultural connections. Cultural elements such as shared meals, traditional decor, and a mid-program break for cultural events were central to participant safety, trust, and meaning making. Indigenous and non-Indigenous participants treated together reported comparable gains, suggesting the model may reduce inequities in group KAT delivery. Challenges included stigma, systemic barriers, and logistical obstacles in a rural First Nation setting.

DOI: 10.3389/fpsyt.2026.1722573 Full text Culturally integrated care Evidence in practice Indigenous mental health Ketamine assisted therapy +1