Evidence in practice: implementing KAT in indigenous health services.
Frontiers in psychiatry January 1, 2026 Jean Jacque Lovely, Hiedi Yardley, Reverdi Darda et al.
A collaborative pilot program between Siksika Health Services and ATMA CENA designed and delivered a culturally responsive ketamine-assisted therapy (KAT) program within the Siksika First Nation in Alberta, Canada. Six participants (3 Indigenous, 3 non-Indigenous) completed care. Notable improvements in symptoms of depression, anxiety, and PTSD were observed, with participants reporting increased emotional regulation and stronger cultural connections. Cultural elements such as shared meals, traditional decor, and a mid-program break for cultural events were central to participant safety, trust, and meaning making. Indigenous and non-Indigenous participants treated together reported comparable gains, suggesting the model may reduce inequities in group KAT delivery. Challenges included stigma, systemic barriers, and logistical obstacles in a rural First Nation setting.