Role of Psychological support in sustaining Antidepressants effects in Psilocybin - Assisted Clinical
JOURNAL OF ADVANCE AND FUTURE RESEARCH May 1, 2026 Gyandev Gupta, Ravina Yadav
Depression is a common mental health challenge that affects thinking, behavior, and quality of life, and standard antidepressants do not work for everyone, often causing side effects or delayed responses. Psilocybin, a compound from certain mushrooms, targets serotonin receptors in the brain, lifting mood and promoting neural adaptability. Animal studies with mice, rats, zebrafish, and fruit flies show reduced depression- and anxiety-like behaviors after psilocybin. Clinical trials using synthetic COMP360 in people with treatment-resistant depression report meaningful improvement within days that lasted for weeks. Psychological support before, during, and after the experience is as important as the compound itself, making psilocybin-assisted therapy a whole-person approach.