Ravina Yadav

2 papers in the library · publishing 2026

Papers

Role of Psychological support in sustaining Antidepressants effects in Psilocybin - Assisted Clinical

JOURNAL OF ADVANCE AND FUTURE RESEARCH May 1, 2026 Gyandev Gupta, Ravina Yadav

Depression is a common mental health challenge that affects thinking, behavior, and quality of life, and standard antidepressants do not work for everyone, often causing side effects or delayed responses. Psilocybin, a compound from certain mushrooms, targets serotonin receptors in the brain, lifting mood and promoting neural adaptability. Animal studies with mice, rats, zebrafish, and fruit flies show reduced depression- and anxiety-like behaviors after psilocybin. Clinical trials using synthetic COMP360 in people with treatment-resistant depression report meaningful improvement within days that lasted for weeks. Psychological support before, during, and after the experience is as important as the compound itself, making psilocybin-assisted therapy a whole-person approach.

DOI: 10.56975/jaafr.v4i5.509087 Full text Psilocybin Anxiety Depression economics Social support +5

Harnessing Neural Resiliency: A Comprehensive Review of Emerging Neuroplasticity Promoters and Their Clinical Efficacy in Depression Management

JOURNAL OF ADVANCE AND FUTURE RESEARCH April 1, 2026 Ashish Yadav, Ravina Yadav

Depression involves impaired brain neuroplasticity, and brain-derived neurotrophic factor (BDNF) is a key marker of this process. A meta-analysis of 20 studies with 1504 participants found that BDNF levels significantly increase after antidepressant treatment, with a moderate effect size of 0.62. Higher BDNF levels correlated with greater improvement in depression scores. Before treatment, depressed patients had markedly lower BDNF than healthy individuals; after treatment, levels improved but remained slightly lower. Chronic stress and depression are linked to neuronal atrophy in the hippocampus and prefrontal cortex. Emerging treatments like ketamine and non-invasive brain stimulation (transcranial magnetic stimulation) may enhance neuroplasticity and offer faster relief.

DOI: 10.56975/jaafr.v4i4.508090 Full text Neuroplasticity Major depressive disorder Treatment-resistant depression Synaptic plasticity +16