Effect of Liner Properties on the Analysis of Lysergic Acid Diethylamide (LSD) Analogs
ChemRxiv Sarah Shuda 1 citation
LSD and related psychedelic drugs are often present at low concentrations on forensic evidence, requiring sensitive detection. The liner inside the injection port of a gas chromatograph (GC) affects how well these compounds are vaporized and transferred to the column. Testing twelve different liners—varying in shape, packing material, and chemical deactivation—showed that liners containing packing material (like glass wool) produced significantly higher peak areas than unpacked liners. Liner geometry had a smaller effect, only mattering with one deactivation type when glass wool was absent. Base deactivation improved peak area compared to standard and Topaz deactivation in straight liners with packing. Over seventy sample runs, base-deactivated and standard liners maintained consistent response, while Topaz-deactivated liners lost 52–68% response after the first injection and 30–54% from first to last injection.