Toward a framework for psychedelic clinical trials in adolescents
Child and Adolescent Psychiatry and Mental Health March 10, 2026 Christine K. Moore, Henry Riordan, Rolana Avrumson et al. 1 citation
Psychedelic therapies show promise for adult mental health conditions, and there is growing interest in testing them in adolescents, who often experience these disorders earlier in life. Regulatory agencies are expected to require trials in younger populations after adult approvals. This paper outlines key considerations for designing and conducting such trials, including safeguards and best practices tailored to adolescents. It builds on adult trial methods and emphasizes increased psychological support and rigorous oversight. The goal is to ensure future adolescent trials are safe, ethical, and meet high scientific and regulatory standards, fostering patient-focused dialogue.