The Differentiation of Lysergic Acid Diethylamide (LSD) from N-Methyl-N-Propyl and N-Butyl Amides of Lysergic Acid
Journal of Forensic Sciences May 1, 1989 Cc Clark 12 citations
Six amide variants of lysergic acid were synthesized to test whether electron impact mass spectroscopy (EI/MS), combined with other analytical methods, can reliably distinguish lysergic acid diethylamide (LSD) from similar compounds. The C8 axial and equatorial isomers were separated by preparative thin-layer chromatography, then analyzed using gas-liquid chromatography, thin-layer chromatography, high pressure liquid chromatography, and EI/MS. The combination of EI/MS with these other techniques successfully differentiated LSD from all other amides tested.