POTENCIAL TERAPÊUTICO DA HOASCA NO TRATAMENTO DA DEPRESSÃO: REVISÃO DE ESCOPO
Revista Políticas Públicas & Cidades April 2, 2026 Adrian Santos de Souza, Endiamara Magda Segala Shigemori, Celso Ferraz Bett
Depression is a leading cause of disability worldwide, and conventional treatments have limitations such as delayed onset and resistance. Hoasca (ayahuasca), an Amazonian infusion containing Banisteriopsis caapi and Psychotria viridis, shows promise as a rapid and lasting antidepressant. This review of 12 studies from 2016–2024 found that its antidepressant effects stem from the interaction between DMT and β-carboline alkaloids, which inhibit MAO, increase serotonin availability, and stimulate BDNF production. Clinical results indicate significant reductions in depressive and anxiety symptoms, improved mood, and reduced suicidal ideation, with effects appearing within 24 hours and lasting up to 21 days. The ritual context, emotional preparation, and setting also influence therapeutic response. Hoasca appears to be a promising adjunct for depression, but more controlled trials are needed.