Endogenous N,N-dimethyltryptamine (DMT) is a naturally occurring psychedelic compound with unique biological and physiological properties that may influence nervous system function. The review describes DMT's biosynthesis, metabolism, and interactions with receptors, particularly sigma-1 and trace amine-associated receptors, beyond its well-known action at serotonin 5-HT2A receptors. It discusses DMT's potential roles in neuroplasticity, neuroprotection, and modulation of consciousness, as well as its possible involvement in endogenous states such as dreaming, near-death experiences, and psychosis. The authors suggest that DMT may act as a neurotransmitter or neuromodulator with effects on cognitive and emotional processes, highlighting its therapeutic potential for neurodegenerative and psychiatric disorders.
N,N-dimethyltryptamine (DMT), a naturally occurring psychedelic compound, shows promise for treating psychiatric conditions such as depression, anxiety, and addiction, as well as neurodegenerative disorders like Alzheimer's and Parkinson's disease. DMT acts primarily on serotonin receptors, particularly the 5-HT2A subtype, and also interacts with sigma-1 receptors, which may contribute to neuroprotective and anti-inflammatory effects. The review discusses DMT's mechanisms, including its ability to promote neuroplasticity and reduce neuroinflammation. While preclinical evidence is encouraging, the authors note that clinical research remains limited, and further studies are needed to establish safety and efficacy in humans.