People who use the psychoactive mushroom Amanita muscaria (fly agaric) report more positive than negative effects, and the negative effects are typically mild and temporary. This conclusion comes from analyzing 998 main posts and 9,542 comments on the Reddit forum r/AmanitaMuscaria. Users described reasons for consumption, modes of use, and both beneficial and adverse outcomes. The findings suggest that medical providers may not easily learn about a patient's use of this mushroom unless severe side effects occur. Further research into the mushroom's pharmacology and deeper analysis of online discussions is recommended to inform safe practices.
An analysis of 500 high-engagement threads (12,852 comments) from the r/TherapeuticKetamine subreddit found that people primarily use ketamine for mood-related concerns (53%). Positive effects, most often improved emotional well-being (65%), were reported alongside adverse effects that were predominantly psychological or mood-related (56%). 70% of reported doses exceeded 149 mg, indicating a trend toward higher doses. Intravenous administration (40%) and sublingual troches (23%) were the most common routes. Concurrent use of prescribed psychotropics, cannabis, and psychedelics was also reported. The findings suggest substantial heterogeneity in individual experiences and underscore the importance of clinical monitoring for addiction potential and drug interactions.