The effect of repeated-intermittent exposure to 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) during adolescence on learning and memory in adult rats.
Pharmacological reports : PR October 1, 2018 Karolina Noworyta-Sokołowska, Anna Maria Górska, Krystyna Gołembiowska 5 citations
Repeated intermittent exposure to the hallucinogenic novel psychoactive substance 5-MeO-DIPT during adolescence impaired adult rats' exploratory activity in the open field test, reducing the number of crossings, and impaired learning in the serial pattern learning test, suggesting deficits in long-term memory and cognitive flexibility. No change was observed in the novel object recognition test. The findings indicate that adolescent exposure to 5-MeO-DIPT can cause long-lasting behavioral changes that persist into adulthood.