Proposal of 5-methoxy-N-methyl-N-isopropyltryptamine consumption biomarkers through identification of in vivo metabolites from mice.
Journal of chromatography. A July 28, 2017 D Fabregat-Safont, M Barneo-Muñoz, F Martinez-Garcia et al. 24 citations
A new psychoactive substance, 5-methoxy-N-methyl-N-isopropyltryptamine, has emerged after the control of a similar compound, 5-methoxy-N,N-diisopropyltryptamine. This substance was detected in two pill samples from a Spanish smart shop. The metabolism and pharmacokinetics were studied in adult male mice using ultra-high performance liquid chromatography coupled to high resolution mass spectrometry. Four metabolites were identified. The O-demethylated metabolite and the non-metabolised parent compound are proposed as consumption markers in hydrolysed urine. These findings will assist hospitals and forensic laboratories in monitoring consumption and potential intoxication cases related to this tryptamine.