Study on the Brain Metabolomic Changes of 4-HO-MiPT Infected Zebrafish by UHPLC-Q/Orbitrap HRMS
Zhipu Xuebao September 19, 2024 Yu-Bin Chen, Jiao-Yuan Yu, Liang Meng et al.
In zebrafish injected with 4-HO-MiPT, movement speed and range dropped sharply, indicating altered locomotor activity. Brain analysis identified 37 differential metabolites—7 elevated and 30 reduced—along with changes in 6 metabolic pathways. Transcriptional levels of genes related to the nervous system decreased, suggesting impacts on neuronal function and synaptic transmission. The findings indicate neurotoxic effects on the zebrafish brain, affecting both nervous and immune systems, and potential carcinogenicity was noted, highlighting the need for risk assessment and regulation.