Meng Liu

Affiliated Tumor Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830011, China.

2 papers in the library · 1 citation · publishing 2024

Papers

Pathophysiological impacts of 5-MeO-MiPT on zebrafish (Danio rerio) via the Gαq/11-PLCβ signaling pathway

Ecotoxicology and Environmental Safety August 30, 2024 Sen Zhao, Meng Liu, Jinyuan Chen et al. 1 citation

5-Methoxy-N-isopropyl-N-methyltryptamine (5-MeO-MiPT), a tryptamine-derived novel psychoactive substance detected in aquatic environments, alters gene expression and disrupts signaling pathways in zebrafish. After 30 days of injection with varying concentrations, RNA-seq, qPCR, metabolomics, and histopathology showed that 5-MeO-MiPT significantly affects the transcription of 13 genes, including ucp1, pet100, grik3, and grik4, via the Gα q/11-PLCβ signaling pathway. The substance inhibits DAG-Ca2+/Pkc/Erk, Pkc/Pla2/PLCs, and Ca2+/CamkII/NMDA pathways while enhancing Ca2+/Creb, mechanisms that may mediate behavioral inhibition and oxidative stress. These findings clarify toxicological and addiction mechanisms of 5-MeO-MiPT and suggest approaches for studying other tryptamine-based NPS and diagnosing liver-brain pathway diseases.

DOI: 10.1016/j.ecoenv.2024.116969 Zebrafish Danio Oxidative stress Gene expression +6

Study on the Brain Metabolomic Changes of 4-HO-MiPT Infected Zebrafish by UHPLC-Q/Orbitrap HRMS

Zhipu Xuebao September 19, 2024 Yu-Bin Chen, Jiao-Yuan Yu, Liang Meng et al.

In zebrafish injected with 4-HO-MiPT, movement speed and range dropped sharply, indicating altered locomotor activity. Brain analysis identified 37 differential metabolites—7 elevated and 30 reduced—along with changes in 6 metabolic pathways. Transcriptional levels of genes related to the nervous system decreased, suggesting impacts on neuronal function and synaptic transmission. The findings indicate neurotoxic effects on the zebrafish brain, affecting both nervous and immune systems, and potential carcinogenicity was noted, highlighting the need for risk assessment and regulation.

DOI: 10.7538/zpxb.2023.0126 Full text 4-hydroxy-n-methyl-n-isopropyltryptamine 4-ho-mipt Zebrafish Behavioral model Metabolomics