Neurovascular Architecture Of The Brain As A Limit Of Biological Reproducibility: From The Connectome And Vasculome To The Problem Of Consciousness Identity
Zenodo (CERN European Organization for Nuclear Research) June 1, 2026 Юр'єв Віктор Єгорович Viktor Yuriev
The human brain is an integrated neurovascular system where neurons, blood vessels, glial cells, and metabolism work together. Neurovascular coupling, the blood–brain barrier, and the glymphatic system support cognitive processes. The vasculome is proposed as an additional organizational level alongside the connectome. Current brain reconstruction approaches have limitations, leading to a Biological Non-Reproducibility Principle for complex self-organizing systems. A neurovascular limit of consciousness hypothesis suggests conscious experience depends on sustained energetic and metabolic integration, not just neural architecture. Reproducing the brain cannot be reduced to copying neuronal connections. This perspective reshapes understanding of consciousness continuity, personal identity, and future brain bioengineering.