Preksha Dhyana meditation modulates the serum metabolome in healthy and meditation-naïve participants.
Frontiers in molecular biosciences January 1, 2026 Bassam Abomoelak, Nidhi Kapoor, Mary Schreck et al.
After eight weeks of Preksha Dhyana meditation, healthy novice college students showed higher blood levels of four metabolites—hypoxanthine, oxoproline, choline, and cystine—along with several lysophosphatidylcholine and lysophosphatidylethanolamine species. These changes were linked to pathways involved in cellular energy balance, membrane integrity, and protection against oxidative stress. Multi-omics analysis revealed correlations between these molecules, DNA methylation sites, and cognitive outcomes. The findings suggest that the wellbeing experienced after this meditation practice may be associated with bioactive metabolites and lipids that could act as epigenetic modifiers.