Lisuride, a drug that activates the serotonin 2A receptor but preferentially stimulates G protein over β-arrestin signaling, produced few hallucinogenic-like behaviors (head twitches) in mice, unlike LSD. In wild-type and β-arrestin knockout mice, lisuride reduced locomotion and rearing, increased then decreased grooming in βArr2 knockouts, and decreased serotonin syndrome responses especially in βArr2 knockouts. Prepulse inhibition was disrupted only in βArr1 knockouts at 0.5 mg/kg, and this effect was not reversed by a 5-HT2A antagonist but was normalized by clozapine and other drugs. In vesicular monoamine transporter 2 mice, lisuride reduced immobility in the tail suspension test and promoted sucrose preference for up to two days, suggesting antidepressant-like effects without hallucinogenic actions.
After eight weeks of Preksha Dhyana meditation, healthy novice college students showed higher blood levels of four metabolites—hypoxanthine, oxoproline, choline, and cystine—along with several lysophosphatidylcholine and lysophosphatidylethanolamine species. These changes were linked to pathways involved in cellular energy balance, membrane integrity, and protection against oxidative stress. Multi-omics analysis revealed correlations between these molecules, DNA methylation sites, and cognitive outcomes. The findings suggest that the wellbeing experienced after this meditation practice may be associated with bioactive metabolites and lipids that could act as epigenetic modifiers.