The identification and determination of lysergic acid diethylamide in narcotic seizures
Journal of Pharmacy and Pharmacology April 1, 1964 K Genest, C G Farmilo 48 citations
Thin layer chromatography with Ehrlich's reagent spray can identify and determine lysergic acid diethylamide (LSD) in mixtures containing heroin, other narcotics, and controlled drugs. When ergot alkaloids are present, confirmation requires additional thin layer chromatography after ultraviolet irradiation and acid hydrolysis. Spectrophotofluorometric analysis measures LSD with a standard error of ±2% even when heroin or other controlled drugs are present. If ergot alkaloids interfere, thin layer separation followed by elution and fluorometric analysis is recommended.