Psilocybin-assisted psychotherapy for depression: Emerging research on a psychedelic compound with a rich history.
Journal of Neurological Sciences December 1, 2021 Craig S Pearson, J. Siegel, J. Gold 30 citations
Psilocybin-assisted psychotherapy shows rapid and sustained antidepressant effects for individuals with major depressive disorder and treatment-resistant depression. This review covers the history, pharmacology, and proposed mechanism of psilocybin, and describes several published studies from the last decade demonstrating its efficacy and safety. It also discusses limitations and barriers in current psychedelic research, contextualizing results within the current treatment landscape and the pathophysiology of depression.