Adolescent Psychedelic-Assisted Therapy
Acta Psychedelica April 16, 2026 B. Insua-Summerhays, Edward Jacobs
Adolescent depression requires a distinct approach to psychedelic-assisted therapy due to age-related differences in psychology, biology, and social dependence. Unlike adults, adolescents have less autonomy and are more influenced by their family and social environment, which creates a unique risk-benefit profile when using pro-plasticity psychedelics. The authors advocate for a systems-psychological treatment model that includes expanded screening, psychosocial formulation, family psychoeducation, and tailored integration and post-trial support. This interdisciplinary framework addresses the socio-ecological context in which adolescent psychopathology emerges, aiming to make psychedelic-assisted therapy safe, effective, and ethically sound for this population.