Brief report: The influence of childhood trauma on the effects of delta-9-tetrahydrocannabinol in persons with opioid use disorder.
The American journal on addictions May 1, 2024 Michael Rogan, Julio C Nunes, Catherine Z Xie et al. 2 citations
Greater childhood trauma is linked to lower aversive effects from higher doses of THC in people being treated with methadone for opioid use disorder. In a placebo-controlled crossover trial with 25 participants, those with more childhood trauma reported fewer negative subjective effects after taking 20 mg of oral THC. This reduced sensitivity to THC's aversive effects may contribute to increased cannabis use among individuals with opioid use disorder. The findings highlight the importance of assessing childhood trauma in opioid use disorder treatment and research.