Psychedelic‐assisted therapy for functional neurological disorders: a review of the literature
European psychiatry April 1, 2025 T. Fernandes, J. G. Freire, M. C. Pais et al.
Only nine studies, published between 1954 and 1967, have examined psychedelic-assisted therapy for functional neurological disorders (FND). Across 22 patients, 69% (18 individuals) showed at least some recovery, but the studies were low quality, often lacking control groups and valid outcome measures. There is insufficient evidence to support the efficacy of psychedelic-assisted therapy for FND. The discussion continues because abnormalities in default mode network activity have been reported in FND, and some proposed benefits of psychedelics may relate to their action on that network.