U.S. Psychedelic Use and Microdosing in 2025: Insights from a Probability-Based and Nationally Representative Survey.
Rand health quarterly June 1, 2026 M. Priest, B. Kilmer, Ben Senator et al.
Use of psychedelic substances is becoming more common in the U.S., with several states considering policies to decriminalize or legalize them for nonmedical use. Survey data on 11 psychedelic substances show that microdosing—taking a small, sub-hallucinogenic dose on a regular schedule—is a prevalent practice, especially for psilocybin, LSD, and MDMA. The findings provide new information to inform policy debates about alternatives to prohibition.