Artemisia absinthium L. (Wormwood) Extract Effect on 3,4-Methylenedioxymethamphetamine Withdrawal in Rats: An Animal Study.
Addiction & health January 1, 2025 Mohadese Kamali, Hoda Kamali, Arezoo Saberi et al.
In rats, a 10% or 25% ethanolic extract of Artemisia absinthium (wormwood) reduced the severity of certain withdrawal symptoms—such as writhing, body dragging, teeth chattering, and diarrhea—induced by MDMA and naloxone. Lower concentrations (5%) and the MDMA-only group were not well tolerated. The extract's anti-inflammatory, antioxidant, and neuroprotective properties may underlie these effects, but further research is needed to optimize dosing for managing addiction withdrawal.