Efficacy of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for posttraumatic stress disorder: A systematic review and meta-analysis.
Progress in Neuro-psychopharmacology and Biological Psychiatry January 1, 2020 A. Bahji, Ashleigh Forsyth, D. Groll et al. 85 citations
MDMA-assisted psychotherapy shows promise as a safe and effective treatment for chronic, treatment-refractory posttraumatic stress disorder (PTSD). A systematic review and meta-analysis of five randomized trials involving 106 participants (average age 35–40 years, 70% female) found that MDMA-assisted psychotherapy produced a high rate of clinical response and remission, with a large effect size in reducing PTSD symptoms. The treatment was well-tolerated, with few serious adverse events. However, larger studies with longer follow-up are needed to confirm these findings.