Cristina Mustata

2 papers in the library · 100 citations · publishing 2009-2012

Papers

Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”): The Influence of Gender and Genetics (CYP2D6, COMT, 5-HTT)

PLoS ONE October 24, 2012 Ricardo Pardo-Lozano, M. Farré, Samanta Yubero-Lahoz et al. 67 citations

A single oral weight-adjusted dose of MDMA (1.4 mg/kg) produced similar plasma concentrations and positive subjective effects in healthy recreational users regardless of gender or CYP2D6 and COMT genotypes. Female subjects experienced more intense physiological effects (increased heart rate and oral temperature) and negative effects (dizziness, sedation, depression, psychotic symptoms). Genotypes of COMT val158met or 5-HTTLPR with high functionality led to greater cardiovascular effects, while low-functionality genotypes were linked to negative subjective effects. The contribution of MDMA pharmacokinetics to gender differences in drug effects appears negligible; instead, 5-HTTLPR and COMT val158met genotypes play a major role.

DOI: 10.1371/journal.pone.0047599 Full text Medicine Psychology

Spice drugs: los cannabinoides como nuevas drogas de diseño

Adicciones September 1, 2009 Cristina Mustata, Marta Torrens, Ricardo Pardo et al. 33 citations

Since 2004, herbal smoking blends sold under the brand Spice drugs have been available online and in smart shops, advertised as aromatic incense not for human use. Users report effects similar to cannabis, and forensic analyses have identified potent synthetic cannabinoid agonists such as JWH-018, CP 47497, JWH-073, and HU-210 in these products. Very little data exist on their pharmacological properties in animals, and no information on their toxicity is available. Their pharmacology, toxicology, and safety in humans remain largely unknown, with only user reports from Internet forums. Neither the plant ingredients nor the identified cannabinoids are listed in the UN 1961 or 1971 controlled substance conventions. Some countries have recently taken legal action to prohibit or control these products.

DOI: 10.20882/adicciones.227 Cannabis Synthetic cannabinoids Spice Designer drug +5