Ketamine: Mechanisms and Relevance to Treatment of Depression.
Annual Review of Medicine September 20, 2023 Ji-Woon Kim, Kanzo Suzuki, E. Kavalali et al. 105 citations
Ketamine produces rapid and sustained antidepressant effects in patients with major depressive disorder that has not responded to conventional monoamine-based drugs. Recent preclinical studies have begun to clarify the mechanisms underlying these effects. This review compares clinical and preclinical findings to provide a broad perspective on how ketamine works as an antidepressant.