Evaluation of Early Ketamine Effects on Belief-Updating Biases in Patients With Treatment-Resistant Depression
JAMA psychiatry September 28, 2022 H. Bottemanne, O. Morlaàs, A. Claret et al. 59 citations
In patients with treatment-resistant depression, a single ketamine infusion shifted belief updating toward a more optimistic bias within 4 hours. This early cognitive change was characterized by stronger asymmetrical reinforcement learning and, after one week of treatment, mediated the clinical antidepressant effect. The findings offer new insights into how fast-acting antidepressants alter cognition, which could be harnessed to promote lasting clinical improvement and treatment responsiveness.