Combination therapy with transcranial magnetic stimulation and ketamine for treatment-resistant depression: A long-term retrospective review of clinical use
Heliyon August 1, 2019 S. Best, D. Pavel, N. Haustrup 34 citations
Combining transcranial magnetic stimulation (TMS) with biomarker-determined ketamine infusions (CTK) is an effective long-term therapy for treatment-resistant depression. In a retrospective review of 28 patients, the mean Clinical Global Impression severity score dropped by 4.46 points after treatment, and this improvement remained stable two years later. The coincident administration of ketamine allowed patients to tolerate higher TMS intensities than they otherwise could. This suggests CTK is a safe and durable option for treatment-resistant depression.