Marina Golts

2 papers in the library · 24 citations · publishing 2021-2022

Papers

Ketamine as Potential Treatment for Postpartum Depression: A Narrative Review

Annals of Clinical Psychiatry November 1, 2022 David Chen‐li, Leanna M.W. Lui, Joshua D. Rosenblat et al. 22 citations

Postpartum depression (PPD) is a severe mood disorder affecting mothers and children, and there is a need for rapid-acting treatments. This narrative review examined the available literature on ketamine for PPD, searching databases for preclinical studies, clinical trials, and reviews. Four clinical trials were identified. The review suggests that ketamine may be a favorable option due to its antidepressant and analgesic effects, short infusion time, and rapid clearance from the mother's bloodstream. However, evidence is insufficient to support its routine use, highlighting the need for more clinical research.

DOI: 10.12788/acp.0082 Ketamine Depression economics Postpartum depression Psychology +5

Role of the Pharmacist in Managing Treatment-Resistant Depression: A Focus on Ketamine

Pharmacy June 25, 2021 Linda Xing Yu Liu, Marina Golts, Virginia Fernandes 2 citations

Depression is especially debilitating when patients do not respond to multiple treatments, a condition called treatment-resistant depression (TRD). Ketamine, an anesthetic that blocks NMDA receptors, has recently shown effectiveness for TRD when given intravenously or intranasally. However, in Canada, access is limited by prescribing restrictions, high costs, and slow adoption of evidence-based practice. The authors argue that novel approaches should be adopted through a multidisciplinary effort, with pharmacists playing a key role in disseminating evidence, collaborating with prescribers, addressing barriers, and managing medication access during transitions of care to improve management of TRD.

DOI: 10.3390/pharmacy9030118