Antidepressant and anti-suicidal effects of ketamine in treatment-resistant depression associated with psychiatric and personality comorbidities: A double-blind randomized trial.
Journal of Affective Disorders January 6, 2023 G. Ahmed, Y. Elserogy, G. M. A. Elfadl et al. 24 citations
Ketamine infusions reduce suicidal ideation and depression in people with treatment-resistant depression, regardless of other psychiatric or personality disorders. In a randomized double-blind trial with 36 patients, those receiving two weekly ketamine infusions showed significantly greater decreases on the Hamilton Depression Rating Scale and Suicide Probability Scale than those given a placebo. The presence of other psychiatric symptoms did not influence the magnitude of improvement. Receiving ketamine was the only significant factor predicting better suicide and depression scores. The study lacked data on quality of life and cognition and had a small sample size.