Changes in white matter microstructure following serial ketamine infusions in treatment resistant depression
Human Brain Mapping January 30, 2023 B. Taraku, R. Woods, Michael Boucher et al. 23 citations
In treatment-resistant depression, four intravenous ketamine infusions (0.5 mg/kg) given over 2–3 days led to significant improvements in depression and anhedonia scores. Brain scans revealed decreased neurite density in occipitotemporal white matter pathways after treatment. Greater reductions in anhedonia correlated with decreased neurite density in the left internal capsule and left superior longitudinal fasciculus. No significant changes were seen in other white matter measures. The neurite orientation dispersion and density imaging model may detect ketamine-induced white matter changes more sensitively than standard diffusion tensor imaging.