Ketamine supresses REM sleep and markedly increases EEG gamma oscillations in the Wistar Kyoto rat model of treatment-resistant depression.
Behavioural Brain Research May 1, 2023 S. Kantor, Michael Lanigan, Lauren Giggins et al. 11 citations
Wistar-Kyoto (WKY) rats, a model of treatment-resistant depression, show increased REM sleep, fragmented sleep-wake patterns, and higher EEG delta power during non-REM sleep compared to Sprague-Dawley (SD) rats. Ketamine suppressed REM sleep and increased EEG gamma power during wakefulness in both strains, but the gamma increase was nearly twice as large in WKY rats. Ketamine also increased beta oscillations only in WKY rats. Plasma concentrations of ketamine and its metabolites were similar in both strains, suggesting the differences are not due to metabolism. These findings support acute REM sleep suppression as a measure of antidepressant responsiveness.