Effect of Ketamine on Sleep in Treatment-Resistant Depression: A Systematic Review
Pharmaceuticals April 1, 2023 Aleksander Kwaśny, A. Włodarczyk, Damian Ogonowski et al. 27 citations
Ketamine reduces the severity of sleep insomnia in depression. Two studies reported significant improvement in sleep measured by MADRS and QIDS-SR16 scales after intravenous ketamine and intranasal esketamine. One case report showed mitigation of symptoms in PSQI and ISI during 3-month treatment with esketamine. Two studies with objective nocturnal EEG measurements showed a decrease in nocturnal wakefulness accompanied by an increase in slow wave and REM sleep. Robust data are lacking, and more research is needed.