At-home ketamine-assisted therapy with remote monitoring produced rapid and significant improvements in depression and anxiety. Among 1247 patients, 62.8% showed at least 50% improvement on the depression scale and 62.9% on the anxiety scale, with remission rates of 32.6% and 31.3%, respectively. Deterioration was rare (0.9% for depression, 0.6% for anxiety). Three patient subpopulations emerged: those who improved steadily (79.3%), those with delayed improvement (9.3%), and a chronic group (11.4%) who were more likely to report dissociation at the fourth session. Side effects at the second session predicted delayed improvement. Only six patients discontinued early due to side effects or adverse events, indicating that screening and monitoring kept risks low.
Multi-voxel pattern analysis (MVPA) of fMRI data can identify five different internal attention states—breath attention, mind wandering, self-referential processing, attention to feet, and attention to sounds—in individual participants with accuracy well above chance (41% vs. 20% chance). In a mixed sample of 16 experienced meditators and novice controls, classifiers trained during a directed attention task successfully recognized these states in 87.5% of participants. When applied to a separate 10-minute meditation session, the classifiers indicated that participants spent more time attending to breath than to mind wandering or self-referential processing. The findings demonstrate the feasibility of using MVPA to objectively measure internal mental states during meditation at the individual level.