A transdiagnostic systematic review and meta-analysis of ketamine’s anxiolytic effects
medRxiv December 11, 2022 Hannah Hartland, Kimia Mahdavi, L. Jelen et al. 22 citations
Ketamine reduces anxiety symptoms within 12 hours of administration, and the effect lasts for 1 to 2 weeks. A systematic review and meta-analysis of 14 randomized controlled trials found significant reductions in anxiety scores compared to placebo at acute (less than 12 hours), subacute (24 hours), and sustained (7–14 days) time points. Improvements in anxiety and depression symptoms were correlated at 24 hours and at 7–14 days. The relationship between peak dissociation and anxiety improvement was not significant. Most studies had a high risk of bias.