The ketamine analog methoxetamine: a new designer drug to threaten military readiness.
Military Medicine September 29, 2014 Cassandra Craig, George H Loeffler 22 citations
Methoxetamine is a dissociative designer drug sold as a legal alternative to ketamine, acting on NMDA and serotonin receptors. Marketed as 'bladder friendly,' it may cause renal and cystic toxicity similar to ketamine. Users experience dissociation and, at high doses, an 'm-hole' of extreme depersonalization. Thirteen cases of acute toxicity show a toxidrome of dissociation, delirium, sympathetic activation, and cerebellar symptoms. The drug is not detected in standard urine tests. Management is supportive with benzodiazepines, antiemetics, IV fluids, and respiratory support. Usage may increase in the United States in early 2014, following a typical two-year lag from Europe.