Therapeutic use of ayahuasca: a review of the evidence of its use in approaching depressive disorders
European psychiatry June 1, 2022 G. Simões, S. Jesús, R. Silva 1 citation
Ayahuasca, a psychotropic plant used by indigenous Amazonians, shows promise for treating depression. A review of six studies found that ayahuasca use was associated with reductions in depression scale scores, significant antidepressant effects, and improved grief symptoms. It also increased introspection, positive mood, self-acceptance, empathy, openness, and emotional processing. However, the evidence comes from small, variable studies, including retrospective and prospective observational studies, a meta-analysis, and a narrative review. The authors conclude that the results are promising but require further investigation in controlled trials with larger samples to better assess clinical effects, safety, and short- and long-term outcomes.