Bistable Perception Discriminates Between Depressive Patients, Controls, Schizophrenia Patients, and Their Siblings.
Schizophrenia bulletin November 10, 2025 Elahe Arani, Simona Garobbio, Maya Roinishvili et al. 3 citations
People with schizophrenia rely less on prior experiences when interpreting visual stimuli, leading to faster perceptual switches in a bistable perception task called Structure-from-Motion (SfM). In the intermittent version of this task, patients with schizophrenia and their unaffected siblings showed significantly higher alternation rates than healthy controls, while patients with depression had the lowest alternation rates. In the continuous version, only patients with schizophrenia had shorter percept durations. The intermittent SfM paradigm may serve as an endophenotype for schizophrenia, reflecting altered adaptation or cross-inhibition mechanisms that affect prior processing.