Parkinson disease psychosis: from phenomenology to neurobiological mechanisms.
Nature reviews. Neurology March 1, 2024 Javier Pagonabarraga, Helena Bejr-Kasem, Saul Martinez-Horta et al.
Psychosis in Parkinson disease (PDP) includes illusions, hallucinations, and delusions that can appear even early in the disease. While once thought to be solely a side effect of dopaminergic drugs, evidence now shows PDP results from the disease's own brain changes combined with medication. Dysfunction in attentional control, sensory processing, limbic structures, the default mode network, and thalamocortical connections leads to incorrect categorization of stimuli and false percepts. This review covers recent clinical, neuroimaging, and neurochemical findings that may help identify psychotic phenomena early and guide new treatments.