Safety issues of psilocybin and LSD as potential rapid acting antidepressants and potential challenges
Expert Opinion on Drug Safety April 15, 2022 Giordano Novak Rossi, Jaime E. C. Hallak, José Carlos Bouso Saiz et al. 24 citations
In the reviewed studies, no serious adverse events were linked to psilocybin or LSD administration. Most side effects were anticipated, manageable, and temporary. However, concerns persist about certain effects like dissociation, paranoia, and confusion. The authors conclude that larger randomized controlled trials are needed to confirm therapeutic benefits and further assess safety and tolerability.