A three-choice discrimination procedure dissociates the discriminative stimulus effects of d-amphetamine and (±)-MDMA in rats.
Experimental and Clinical Psychopharmacology January 1, 2000 A. K. Goodwin, L. E. Baker 44 citations
MDMA produces subjective effects in humans that are similar to, but distinguishable from, those of psychostimulants. In rats trained to discriminate between MDMA and d-amphetamine using a three-choice operant procedure, cocaine fully substituted for d-amphetamine, while LSD dose-dependently increased MDMA-appropriate responding, reaching nearly complete substitution (78%) for MDMA. The hallucinogen 2,5-dimethoxy-4-bromoamphetamine only partially substituted for MDMA and severely disrupted response rate. Fenfluramine and both isomers of MDA fully substituted for MDMA. The serotonin-receptor antagonist pirenpirone only partially blocked MDMA discrimination.