Naloxone potentiates the disruptive effects of mescaline on operant responding in the rat
Pharmacology Biochemistry and Behavior October 1, 1980 R.L. Commissaris, K.E. Moore, R.H. Rech 8 citations
In food-deprived male rats trained to press a lever for food on a fixed-ratio 40 schedule, mescaline (4.0–10.0 mg/kg) caused a dose-dependent pause in responding, termed a hallucinatory pause. Naloxone alone (1.0–8.0 mg/kg) did not affect responding, but when given as a pretreatment, it significantly and dose-dependently potentiated mescaline's disruptive effects. The findings suggest that the narcotic antagonist naloxone enhances the behavioral effects of the phenethylamine hallucinogen mescaline.